How reliable is PRP?
PRP acts by degranulation of alpha particles in platelets, which contain some growth factors. PRP must be prepared in an anticoagulant state and should be used in grafts, flaps, or wounds within 10 minutes of clot onset.
As platelets are activated by the clotting process, growth factors are secreted from the cell through the cell membrane. In this process, alpha particles fuse to platelet cell membranes, and protein growth factors complete the bioactive state by adding histone and carbohydrate side chains to these proteins.
Studies have shown that adult human mesenchymal stem cells, osteoblasts, fibroblasts, endothelial cells, and epidermal cells express cell membrane receptors for growth factors in PRP. These transmembrane receptors in turn induce the activation of endogenous internal signaling proteins that lead to the expression (unlocking) of normal cellular gene sequences, such as cell proliferation, matrix formation, osteoid formation, collagen synthesis, etc.
Thus, PRP growth factors never enter the cell or its nucleus, they are not mutagenic, they simply accelerate stimulation of normal healing.
After the initial burst of PRP-associated growth factors, platelets synthesize and secrete additional growth factors for the remaining 7 days of their life span. Once platelets are depleted and dead, macrophages that reach the region through platelet-stimulated blood vessels grow inward to take on the role of wound healing regulator by secreting some of the same growth factors as well as others. Thus, the number of platelets in the graft, wound, or blood clot attached to the flap determines how quickly the wound heals. PRP just adds to that number.
1）PRP can enhance bone progenitor cells in host bone and bone grafts and promote bone formation. PRP also contains a variety of growth factors, which can promote cell division and differentiation and promote the repair of the body.
2）Leukocytes in PRP can enhance the anti-infection ability of the injured site, help the body to remove necrotic tissue, and speed up the repair of the injury.
3）PRP contains a large amount of fibrin, which can build a better repair platform for body repair and shrink wounds at the same time.
Is PRP really safe and effective?
1）Autologous blood products
A large number of experimental data have shown that PRP can demonstrate its safety and reliability in many treatments. As an autologous blood product, PRP effectively avoids rejection and disease transmission caused by the application of allogeneic blood during treatment.
2）Coagulation initiator is safe
PRP uses bovine thrombin as a coagulation initiator, enabling simultaneous PRP extraction and surgical procedures. The bovine thrombin used is heat-processed and does not cause infection. And because the amount of bovine thrombin used is so small, it does not enter the body and cause rejection during use.
3）The product is safe and effective
Aseptic techniques are used in PRP preparation, resulting in blood clots that do not cause infection complications and do not cause bacterial growth.
（The contents of this article are reprinted, and we do not provide any express or implied guarantee for the accuracy, reliability or completeness of the contents contained in this article, and are not responsible for the opinions of this article, please understand.）
Post time: Sep-14-2022