A Study on the Application of Platelet Rich Plasma (PRP) in Patients with Atrophic Rhinitis

Primary atrophic rhinitis (1Ry AR) is a chronic nasal disease characterized by a loss of mucociliary clearance function, the presence of sticky secretions and dry crusts, leading to a typical foul odor, usually bilateral. A large number of treatment methods have been attempted, but there is still no consensus on long-term successful curative treatment. The purpose of this study is to evaluate the value of platelet-rich plasma as a biological stimulant for promoting the healing of primary atrophic rhinitis.

The author included a total of 78 cases clinically diagnosed with primary atrophic rhinitis. Group A (cases) and patients with poor platelets underwent nasal endoscopy, Sino Nasal Outcome Test-25 questionnaire, saccharin time trial to evaluate mucosal ciliary clearance rate, and plasma in biopsy specimen Group B (control) 1 month and 6 months before the application of platelet rich plasma.

The most common symptoms encountered by all patients in Group A before injection of platelet rich plasma included nasal scab, which showed endoscopic improvement and reduced incidence, with 36 cases (92.30%); foetor, 31 (79.48%); Nasal obstruction, 30 (76.92%); Loss of smell, 17 (43.58%); And epistaxis, 7 (17.94%) to nasal scab, 9 (23.07%); Feet, 13 (33.33%); Nasal congestion, 14 (35.89%); Loss of smell, 13 (33.33%); And epistaxis, 3 (7.69%), after 6 months, this is reflected in a decrease in the Sino Nasal Outcome Test-25 score, which averaged 40 before platelet rich plasma and decreased to 9 after 6 months. Similarly, the mucociliary clearance time was significantly shortened after injection of platelet rich plasma; The initial average saccharin transport time test was 1980 seconds, and it decreased to 920 seconds 6 months after injection of platelet rich plasma.